3 The management of this tumor at other types of centers may lead to inappropriate tests, 2 positive margins after surgical resection, and a reduced likelihood of radiotherapy. Soft-tissue sarcomas are best treated in multidisciplinary centers that specialize in treating this disease, 2-6 have experience with functional limb preservation, and have low rates of local recurrence and good rates of overall survival. Half of patients with soft-tissue sarcomas will die from this disease, a statistic that has changed little in recent decades. Intraabdominal tumors pose treatment challenges because of the proximity of adjacent vital organs. ![]() Function-preserving limb conservation is the goal of treatment for soft-tissue sarcomas of the limbs. Surgery for localized disease is often curative, alone or in combination with radiotherapy and chemotherapy in selected patients. Soft tissue in this context is defined as nonepithelial extraskeletal tissue, including muscle, fat, and fibrous supporting structures, arising mainly from embryonic mesoderm, with some neuroectodermal contribution.Īccurate pretreatment evaluation is critical for treating soft-tissue sarcomas. Benign soft-tissue tumors, especially lipomas, are 100 times as common. Distribution of Soft-Tissue Sarcoma.Īlthough soft-tissue sarcomas can arise anywhere in the body ( Table 1), the majority occur in the limb or limb girdle or within the abdomen (retroperitoneal or visceral and intraperitoneal). This overview is intended as a review of current understanding and treatment of soft-tissue sarcoma, with an emphasis on recent advances. ![]() Limb-conserving surgical paradigms, superior radiotherapy delivery, and novel adjuvant agents for specific tumors are now available. Advances in multidisciplinary care have improved the evaluation and care of patients with this disease. Soft-tissue sarcomas are uncommon tumors that have traditionally been managed by wide excisional surgery and radiotherapy the use of chemotherapy has been reserved for advanced disease. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. ![]() The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.
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